Postmenopausal Hormone Replacement Therapy and Cardiovascular Disease
نویسنده
چکیده
Heart disease is the leading cause of death among postmenopausal American women. Although early observational studies suggested that hormone replacement therapy (HRT) might decrease these risks, prospective, experimental studies have not supported these results. With the recent release of these data in the media, clinicians are receiving numerous questions concerning HRT. This article reviews the current evidence and provides suggestions on how to address these inquiries.
منابع مشابه
Serum vitamin A status in women users of lowdose oral contraceptives and in postmenopausal women taking hormone replacement therapy.
Background: One of the most important nonenzymatic antioxidant defense systems is vitamin A, and is considered as an important dietary agent for reducing cardiovascular diseases. Objective: The objective of this study was to investigate the serum vitamin A status in women who used low-dose oral contraceptives (OCs) containing 0.15 mg levonorgestrol and 0.03 mg ethinyl estradiol and also in...
متن کاملHormone replacement therapy and stroke: clinical trials review.
Bench research suggests that postmenopausal hormonal therapy is associated with beneficial effects on the brain and vascular system. Observational data suggest that postmenopausal hormone replacement therapy is associated with a 25% to 50% lower rate of cardiovascular disease; however, observational data for hormonal therapy is associated with the potential for significant biases. Clinical tria...
متن کاملEffects of oral hormone replacement therapy on mean platelet volume in postmenopausal women.
BACKGROUND/AIM To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. MATERIALS AND METHODS This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone ...
متن کاملHormone replacement therapy and cardiovascular disease: lessons from a monkey model of postmenopausal women.
Concerns exist about the cardiovascular effects of hormone replacement therapy (HRT) in postmenopausal women because results from the Women's Health Initiative (WHI) and the Heart and Estrogen/Progestin Replacement Study (HERS) are contradictory. In both of these studies, postmenopausal conjugated equine estrogens + medroxyprogesterone acetate did not reduce risk, and somewhat increased the ris...
متن کاملPostmenopausal hormone replacement therapy and cardiovascular disease.
Cardiovascular disease is the leading cause of mortality in postmenopausal women in developed countries. A possible cardioprotective role of hormone replacement therapy (HRT) is suggested by epidemiologic studies of HRT and reduced risk of coronary heart disease, as well as by randomized trials of HRT and lipid subfractions. Estrogen has beneficial effects on the lipid profile, raising high-den...
متن کامل